BLG 311 Lecture 5: Cell-Biology-Lecture5
24 May 2016
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Ser-lys-leu (peroxisomal targeting signal 1) located at the c-terminal of many peroxisomal proteins functions as an import signal. Other peroxisomal proteins contain a signal sequence near the n-terminal (peroxisomal targeting signal. These proteins and their sequences come from the nucleus. Glyoxysomes break down lipids for sugars (type of peroxisome) Ans: addition of these phosphorylation groups interferes with the function of the signal (exportins cannot recognize the signal) Nov. 2nd and 3rd lecture chapter 12. Protein targeting and transport into er is co-translational or post-translational. Co means that the protein is being synthesized the same time on an er associated ribosome that it is being transported into the er. The signal sequence is usually nonpolar amino acids. Post has cytosolic ribosome and the mechanisms used first synthesizes the chain, and s then transported into the er. How are proteins targeted to the er: signal sequence, signal recognition particle (srp, srp receptor, translocation by translocator channel.
