BMS 860 Lecture Notes - Lecture 1: International Agency For Research On Cancer, Schwann Cell, Relative Risk

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Cancer causes 30% of all deaths in canada. 90% of all cancer deaths is due to metastasis. The origin of the word cancer is from the greek karkinos or crab. Microscopic examination of biopsy or surgical specimen tissue after the specimen has been processed and histological sections have been placed onto glass slides. Steps: tissue is isolated from a patient (biopsy or surgical, tissue histology slides are prepared, pathologist reviews the slides and prepares pathology report. To preserve it, tissue is first fixed using formalin based solutions. It is then subjected to processing in which all the water is extracted from the tissue. Paraffin wax is then applied to the tissue, it penetrates the tissue and forms a paraffin block. After embedding, the blocks are cut into very thin sections on a machine called microtome and placed on a slide. Slide is then stained to visualize tissue morphology. Basic analysis of histology slides: abnormalities that can occur in tissue.

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