BMS 860 Lecture Notes - Lecture 14: Vimentin, Desmosome, Beta-Catenin
3 May 2017
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Document Summary
Histophathological characterization of these epithelial tumours reveal that they are composed of a number of distinct cell types. Heterotypic signaling: communication between dissimilar cell types: one of the first clues that stromal cells contribute to tumourigenesis comes from evidence of exchange of signals that occurs between stroma and epithelium. Fgf10 ligand and fgf-r2b receptor, and jagged 1 ligand and notch 3 receptor. In addition, the carcinoma cells have recruited substantial stroma which includes macrophages. Tumours resemble wounded tissues that do not heal: tumour cells are thought to activate a complex normal physiologic program wound healing in their favor to advance tumourigenesis, 4 steps to wound healing: hemostasis, inflammatory, proliferative, remodeling. Attachments of epithelial cells to their neighbors and the bm: epithelial cells are anchored via hemidesmosomes on their basal surfaces to the underlying bm and via their lateral surfaces to adjacent epithelial cells. These lateral connections include tight junctions, adherens junctions and desmosomes and gap junctions.
