FNN 100 Lecture Notes - Lecture 13: Sickle-Cell Disease, Beta-Carotene, Vitamin

• School: Ryerson University
• Department: Nutrition and Food
• Course: FNN 100
• Professor: Barbara Wendland

Document Summary

Oxidation: addition of o2 to a compound. Oxidant: a compound that oxidizes another compound: cmpd that removes electrons from another cmp. Create free radicals (pro oxidants) in the process (promotes oxidation) Antioxidant: inhibits or reverses oxidation free radicals. Unstable atoms (1+ unpaired electrons: o2 containing molecules= highly reactive, take e from others to be stable. No antioxidant balance oxidative stress (imbalance btwn pro oxidants and antioxidants) Formed from environmental factors (and rxns in metabolism like etc) Etc rxn forming water (w/ 2 o2), sometimes instead of 2 o2 1 o2 reactive superoxide. Very reactive: carry odd # e- Changes structure and function of proteins and lipids: damage cells, dna, and cause diseases like cancer, cvd, dm. All cells are exposed to oxidants: environmental, aerobic metabolism. Air pollution, radiation, high blood sugar level (pufas), infection. Smoke, alc, drugs, aging and too much exercise. Prote(cid:272)t agai(cid:374)st o(cid:454)idative da(cid:373)age (cid:271)(cid:455) (cid:862)s(cid:272)ave(cid:374)gi(cid:374)g(cid:863) for u(cid:374)paired ele(cid:272)tro(cid:374)s. Donate e to free radicals: stabilizing them.