PAT 20A/B Lecture 2: (2)PAT20 Fall Week 2 Notes (Inflammation)

• School: Ryerson University
• Department: Pathotherapeutics
• Course: PAT 20A/B
• Professor: Audrey Kenmir

Document Summary

Inflammatory response: a sequential reaction to cell injury that neutralizes and dilutes the inflammatory agent, removes necrotic materials, and establishes an environment suitable for healing and repair. Chemotaxis: mechanism for ensuring accumulation of neutrophils and: cellular monocytes at the focus of injury. Neutrophils are the first leukocytes to arrive at the site of inflammation (usually within 6 to 12 hours). Monocytes are the second type of phagocytic cells that migrate from circulating blood (within 3 to 7 days after the onset of inflammation). Histamine (stored in granules of basophils, mast cells, platelets) = causes vasodilation and increased vascular permeability by stimulating contraction of endothelial cells and creating widened gaps between cells. Serotonin (stored in platelets, mast cells, enterochromaffin cells of gi tract) = causes vasodilation and increased vascular permeability by stimulating contraction of endothelial cells and creating widened gaps between cells; stimulates smooth muscle contraction.