PLN 203 Lecture Notes - Lecture 3: Plasmin, Prostacyclin, Vasospasm
23 Feb 2017
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Most are in connective tissue proper and lymphatic system organs. Small numbers in blood (5000-10,000 per microliter) Midterm question characteristics: can migrate out of bloodstream, have amoeboid movement, attracted to chemical stimuli (positive chemotaxis) toward a higher concentration of the chemical, some are phagocytic (neutrophils, eosinophils, and monocytes) Neutrophils: aka polymorphonuclear leukocytes, 50-70% of circulating wbc, pale cytoplasm granules with: Prolong exercise causses a temporary suppression of immune function. Neutrophils burst, increase in lymphocytes and monocyte antigens: neutrophil action. Very active, first to attack bacteria (increase) Definsins (peptides from lysosomes) attack pathogen membranes. Eosinophils: 2-4% of circulating wbcs, plays a role in allergic reactions, attack large parasites, excrete toxin compounds. Cytotoxic enzymes: sensitive to allergens, control inflammation with enzymes that counteract inflammatory effects of neutrophils and mast cells. Basophils: less than 1% of circulating wbc, accumulate in damage tissue, release histamine (dilates blood vessels, release heparin (prevents blood clotting)
