PSY 214 Lecture Notes - Lecture 5: Choline Acetyltransferase, Acetyl-Coa, Neuromuscular Junction
Document Summary
Autonomic nervous system and somatic ns (neuromuscular junction: acetylcholine primarily act on parasympathetic ns, norepinephrine has more dominant role on sympathetic ns. Vesicles in the terminal are loaded with ach by vesicular ach transporter it can be blocked by a drug called vesamicol- it decreases vesicular ach but increases cytoplasmic ach. Autoreceptors- 2 types- normal type (neg feedback), and another that increases release. After ach is broken down, choline is taken back into the nerve terminal by a choline transporter: choline transporter can be blocked by the drug hc-3, decreasing rate of ach production cholinergic pathways: Basal forebrain cholinergic system (bfcs)- collection of cholinergic nerve calls that play an important role in cognitive functioning, attention and memory. Nicotinic receptors are ionotropic receptors- when ach binds, the channel opens and na+ and. Agonists in nature: pilocarpine and arecoline (both parasympathomimetic agents because ingesting them mimics the effects of parasympathetic activation)
