BISC 101 Lecture Notes - Lecture 6: Metastasis, Cell Adhesion Molecule, Cancer

• School: Simon Fraser University
• Department: Biological Sciences
• Course: BISC 101
• Professor: Onkar Bains

Document Summary

Stop and go signals internal and external signals at the checkpoints. ^another example of external signals is density dependent inhibition. Concept d: loss of cell cycle controls in cancer cells. ^if abnormal cells remain at the origin site, the lump is called a benign tumor. ^malignant tumor invade surrounding tissues and can metastasize. Some differences between normal, healthy cells and cancer cell. Normal cells: ^density dependent inhibition, ^anchorage dependence, ^(no loss of cell cycle function) Cancer cells: ^do(cid:374)"t e(cid:454)hi(cid:271)it de(cid:374)sit(cid:455) depe(cid:374)de(cid:374)t-exhibition, ^do(cid:374)"t e(cid:454)hi(cid:271)it a(cid:374)(cid:272)horage depe(cid:374)de(cid:374)(cid:272)e, ^(loss of cell cycle function) Normal cells: ^have surface adhesion molecules, ^do not have the ability to metastasize (spread, ^develop into specialized cells. Cancer cells: ^do(cid:374)"t ha(cid:448)e surfa(cid:272)e adhesio(cid:374) (cid:373)ole(cid:272)ules, ^have the ability to metastasize, ^do(cid:374)"t de(cid:448)elop i(cid:374)to spe(cid:272)ialized (cid:272)ells.