BISC 101 Lecture Notes - Lecture 19: Molecular Recognition, Phagocyte, Innate Immune System
16 Jun 2016
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Pathogens: can be anything that invades the is i. e. bacteria, virus, ectoparasite, cordyceps. Innate immunity: occurs in all animals and plants, rapid and initial response, small amt of receptors, identifying the invader in your own tissues: immune response is the same regardless if the pathogen has been seen or not. Body must be able to differentiate pathogen from own cell. Molecular recognition: specific receptors (small #) that detect conserved molecules present in many pathogens. Toll-like receptors: 10-11 in mice and humans: detect stuff that don"t occur in animals, tlr4 lipopolysaccharide, tlr3 double stranded rna, tlr5 bacterial flagellum proteins. Recognition: leads to responses to deal w pathogen: phagocytosis/cellular ingestion and digestion of pathogens. Molecular recognition via tlr on phagocytic cells pathogens engulfed by endocytosis and forms vacuole in phagocytic cell vacuole fuses with lysosome toxic chem in lysosome destroy pathogen exocytosis releases remains. Ectotherms can induce fever through behaviour (aka. moving into sun)
