BPK 306 Lecture Notes - Lecture 5: Metabotropic Glutamate Receptor, Metabotropic Receptor, Signal Transduction

• School: Simon Fraser University
• Department: Biomedical Physio & Kines
• Course: BPK 306
• Professor: Sam Doesburg

Document Summary

Learning objectives: explain the differences between ionotropic and metabotropic receptors, and give examples of each. Ionotropic glutamate receptors (iglur) in the retina plasticity: ex. > central pore allows ion flow: homomeric -> composed of the same subunit, *different subunits will affect the channel properties -> ex. Cns: slower but more complex, subunits dissociate and bind to receptor to activate/inactivate channel. Ca2+, etc. ) that have other cellular effects including opening (or closing) ion channels or regulating gene expression. Learning and memory of lecture -> changes strength of reaction from synapse on dendrite: synaptic activity can make long-lasting changes to synaptic structure and funciton. Direct" gating of ion channels by nt binding to its receptor: for ach this is the nicotinic" ach receptor, direct aka ionotropic aka ion channels, metabotropic receptors are gpcrs. Indirect" gating of ion channels downstream of nt binding to its receptor: for ach this is the muscarinic" ach receptor. Gaba agonist -> results in more functioning gaba.