BPK 306 Lecture Notes - Lecture 9: Dlg4, Temporal Lobe, Cadherin
14 Oct 2017
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Lecture 9 molecular basis of learning and memory. Long term potentiation: -> repetitive activation of an afferent pathway to the hippocampus or an intrinsic connection increases the response of pyramidal cells. Ltp responses can last for hours, days, or weeks depending on the system. Involves early and late phases: early -> insertion of receptors from vesicle stores, late -> modification of gene expression and structural changes. 2. describe how ldp is induced, citing specific patterns of activity as well as the receptors and signaling pathways involved. 3. compare and contrast the activity of nmdars and ampars and describe their respective contributions to plasticity. Ampars: permeable to na+ and k+ Inward current at negative mv, positive (outward?) current at positive mv. Nmdars: blocked by mg2+ at rmp, depolarization removes the mg2+ blockage. Kinase ii) pathway: causes insertion of ampa receptors on the postsynaptic membrane from vesicles, exocytosis of ampa receptors, will now have a larger response to subsequent stimulation.
