BPK 431 Lecture 5: BPK 5

• School: Simon Fraser University
• Department: Biomedical Physio & Kines
• Course: BPK 431
• Professor: mariamrosin

Document Summary

Difference between benign and malignancy: can invade and metastasize (malignant) Multi-step model: key change in initiation is a dna mutation, promotion- end up with expansion. How: increased proliferation, in ammation, irritation, toxicity. Invasion and metastasis: 90 % of cancer death because of metastasis, can vary. Speed: can grow slowly ( thyroid, can grow quickly ( melanoma) Fibroblasts- has a rich stroma: myo broblasts- with wound healing, desmoplastic stroma. Sites involved in metastasis: basically it can be everywhere but it has to eat" its way out and such. The membrane has to be loosened up ( from each other and then from the. Cell-cell interactions: cadherins- can be easily mutated in cancers. Without them then everything sort of falls apart. Two similar cells bind: ex. two epithelial cells, heterotypic. Two different cells bind: ex. endothelial to tumour cell, selectins. Cams: cell- cell interactions, latin receptors, integrins. Laminin receptors: can have an increase or the distribution can alter.