HSCI 100 Lecture Notes - Lecture 4: Major Trauma, Sebaceous Gland, Positive Feedback
21 Jul 2013
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Unspecialized cells that divide continually to create a pool of undifferentiated cells for possible use. In bone marrow, brain, skin, liver: more difficult to locate, ready to generate new cells for repair/replace old, difficult to work with & present in small amounts. Umbilical cord stem cells: multipotent: treat leukemia, stem cells on umbilical cord = immature. Less likely for body to reject: easier to extract than from bone marrow, less likely to carry infections, can produce endless supply of blood cells. Embryonic stem cells: pluripotent: can divide continually & specialize in nearly any cell type, unused embryos from fertility clinics. Blastocyst: sphere of cells containing cluster of 20-30 cells (inner cell mass) adhering to one side of sphere. Easy to harvest, divide for years, create stem cell line. Nucleus from somatic body cell transferred to an egg from which the egg nucleus has been removed.
