HSCI 130 Lecture Notes - Lecture 11: Allostatic Load, Hans Selye, Walter Bradford Cannon
17 Mar 2016
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Hans selye: hungarian born canadian working out of mcgill university, pioneer of biological effects of stressful stimuli. Alarm; body recognizes a stressor and is in state of alarm, fight or flight response, Resistance: follows alarm reaction, removal or disappearance of symptoms, reverse reactions of alarm phase. Exhaustion: body s resources are depleted and unable to function normally. Sam system: walter cannon early work on fight or flight, increases secretion of epinephrine and norepinephrine, increases blood pressure, heart rate, sweating, contraction of blood vessels. Consequences: suppression of cellular immune function, increased blood pressure/heart rate, variations normal heart rhythms, neurochemical imbalance. Hpa system: anterior pituitary gland secretes acth, activates the adrenal cortex to produce cortisol and other glucorticoids. Diurnal pattern: peaks early and then declines. Homeostasis: regulation of a limited number of core physiological systems to sustain life. Allostatic load: consequences of sustained activation of primary regulatory systems serving allostasis to burden on bodily systems.
