HSCI 212 Lecture Notes - Lecture 11: Hepatotoxicity, Rifampicin, Lymphatic System
9 Aug 2018
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Document Summary
Cord factor: cell wall component (glycolipid), causes daughter cells to remain attached in parallel inhibits migration of neutrophils, toxic to mammalian cells inhibits killing by macrophages, no cord factor = not infectious. Mycolic acid: waxy lipid, chains of 60-90 carbon atoms. Responsible for unique characteristics: slow growth (takes time to synthesize, protect from lysis after phagocytosis, allows intracellular growth, resistant to drying out. Hiv infection risk factor for development of tb *active: increase in rates of drug resistant tb, including multi-drug and extensively drug resistant tb (mdr-tb & xdrtb); hard to treat and contributes to increased mortality. Primary: (most often) lung infection, development of tb. Secondary/reactivated: (especially in immunocrompromised people) reactivation or infection with new exposure. Disseminated: (aka miliary tb) other sites in the body (throughout organ systems, bloodstream spinal cord, brain bone marrow) Macrophages take up mycobacterium tuberculosis but unable to digest them; cell wall prevents fusion of phagosome with lysosome; bacteria multiply unchecked within macrophage (incubation)
