HSCI 212 Lecture Notes - Lecture 12: Franklin D. Roosevelt'S Paralytic Illness, Pilus, Enterotoxigenic Escherichia Coli
9 Aug 2018
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Document Summary
Agents implicated in diarrheal disease: bacteria, viruses, and protozoa. Rotavirus, e. coli, shigella, campylobacter and salmonella, v. cholera. Major cause of child deaths but most cases among adults and older children. Acute watery diarrhea includes cholera & significant fluid loss, bloody diarrhea, persistent diarrhea. *immunizations help reduce deaths from diarrhea by: preventing infections that cause diarrhea directly eg. rotavirus, preventing infections that can lead to diarrhea as complication of an illness eg. measles. Results in massive efflux of ions and water into intestinal lumen, severe diarrhea and dehydration and collapse of circulatory system death if rehydration therapy not administered, self-limiting disease (bacteria washed out with stool) Survivors have life-long immunity but can be carriers. Virulence factors: environmental factors (ph shock in stomach, rise in temperature, trigger expression of these) Gbpa: a soluble colonization factor binds to receptor on host cells, contributes to adhesion of v. cholera to host cells.
