MBB 322 Lecture Notes - Lecture 5: Dermatan Sulfate, Sulfation, Aggrecan

• School: Simon Fraser University
• Department: Molecular Biology and Biochemistry
• Course: MBB 322
• Professor: Nancy Hawkins

Document Summary

Copy: 4 classes, hyaluronan, no sulfation, heparain/herparan sulfate, chondroitin (dermatan) sulfate, keratan sulfate, very charged, vey hydrophilic, copy. Hyaluronan: simplest gag, forms backbone of complex proteoglycans, can also occur as a free molecule, up to 25000 disaccharide units, again no sulfated sugars, copy rest. Linkage between gag chair and core protein in proteoglycan: core protein synthesized on rough er, assembly of sugars occur in golgi, chondroitin and heparin are o linked, keratin is n linked. Aggrecan: major component of cartilage, backbone of hyaluronan, multiple aggrecan proteins attached non-covalently, copy, mechanical support.