MBB 428 Lecture Notes - Lecture 3: Poliovirus, Vpg, Autocatalysis
9 Feb 2019
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January 22nd, 2019 mbb 428 d100 spring 2019. Assignment 3: ipv is inactivated, meaning it cannot replicate and mutate to an infectious form of the virus. Vp1 molecules: draw vp1, 2, and 3 arrangements (easy, vp4 is on the inside of the capsid, poliovirus printout, answer the following questions about poliovirus infection, poliovirus capsid protein vp1 interacts directly with the host cell receptor pvr. 3dpol: when 3 ab is cleaved by the 3c protease, 3b is released, which is the vpg protein. Rna synthesis requires an rna-dependent rna polymerase that is encoded on the viral genome. Also, it might undergo conformational change that allows injection of the viral rna into the host cell more efficiently: rscb protein data bank question, all viral proteins except ns1 are packaged in/on the virion. Rna that are encapsidated as individual rod-shaped ribonucleoproteins (rnps). Rnp contains a viral rna, a viral polymerase and multiple copies of the viral nucleoprotein.
