MBB 231 Lecture Notes - Lecture 7: Lysosomal Storage Disease, Enzyme Replacement Therapy, Glucocerebroside

• School: Simon Fraser University
• Department: Molec Biol & Biochem
• Course: MBB 231
• Professor: Micheal Silverman

Document Summary

Tutorial questions week of may 27th: fatty acids have a polar carboxyl group as a head, and a non-polar unbranched hydrocarbon chain as the tail. Phospholipids make up the fluid cell membrane, particularly phosphoglycerides, which are made up of 2 fatty acids, one phosphate group attached to a glycerol and an alcohol attached to the phosphate by an ester bond. The two fatty acids often include one saturated fatty acid and one unsaturated. Unlike saturated fatty acids, unsaturated fats have one or more double bond(s) in their tail, which creates a bend in the structure. This prevents the fats from packing closer together, thus providing fluidity to the membrane. The second type of phospholipids is sphingolipids, a long hydrocarbon with one unsaturated site near the polar end. Therefore, cells with accumulated fat build up in the spleen, liver and bone marrow. Oppositely, endocytosis is the uptake of materials into the cell by creating vesicles from the plasma membrane.