MBB 331 Lecture Notes - Lecture 12: Chromosome, Mre11A, Phosphodiester Bond
22 Jul 2020
School
Department
Course
Professor
Document Summary
Homologous recombination: prokaryotes, dsbr, eukaryotes, most occurs in meiosis, the crossover causes this, mitosis, rare, doesn"t happen as often, happens during recombinal mistakes, special case, directed/dedicated way to resort homologous regions. In both: damage resulting in ds breaks. Lecture 11: meiosis, exchange is initiated by breaks, we don"t know about the frequency or what its controlled by, but not random, main purpose is to initiate recombinational events. In general, you"ll always need enzymes to: break dna, process the ends. Load on the ends: facilitate strand invasion. Ligation results in the holliday intermediates: dissolution causes non-crossover repair, resolution cause crossover repair, however, more frequently, it goes to sdsa pathway (pink) If conditions unfavourable for growth, they undergo meiosis: recomb happens and 4 different haploid spores result. It can survive very stressful environments: when conditions are good again, they go back to being haploid cells, how you become an a or an alpha depends on a region in chromosome 3 known as.
