BIOL 1550 Lecture Notes - Lecture 4: Pharmacokinetics, Cyp3A4, Grapefruit Juice
20 Oct 2016
School
Department
Course
Professor
Document Summary
Types of adr"s: pharmacological : based on d-r interaction, predictable, side effects, toxicity, dependence, non-pharmacological: based on d-r interaction, not predictable (toxicity, often more serious (cancer, allergies ) Side effects: extension of therapeutic effect, difficult to avoid, lower dose, may gradually fade, immediate- ex: antihypertension med =syncope (fainting, after time- ex: aspirin = gi ulcer, may necessitate change. Liver: acetaminophen one of 50 drugs that may damage the liver, reduced metabolism, hepatic excretion liver function tests (lfts) Kidney: aspirin, ibuprofen, antibiotics, glomerular filtration rate (gfr, reduces excretion. Ear: deafness, vertigo, aspirin, antibiotics, diuretics. Carcinogenicity: 7 20 year onset, various organs, drug-specific, predict in vitro and with animals, monitor medications for yrs. Teratogen: chemical that increase risk of birth defect. A physical or biochemical abnormality that is present at birth and that may be inherited or the result of environmental influence . X contraindication (never be used in a pregnant women) The opposite of the intended drug response.
