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BIOCH 200 (April 7, 2014) - The Citric Acid Cycle

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Walter Dixon

BIOCH 200 – The Citric Acid Cycle (April 7, 2014) • The major purpose of aerobic CATABOLISM is to “capture” the energy in biological fuel molecules and use it to make ATP. • General Features of the CAC o *Occurs in the matrix o *Oxidizes the acetate in acetyl-CoA  Carbon atoms are converted into CO 2 o *Is a cyclic process  *Starts and ends with oxaloacetate (OAA)  *Is the final stage in the AEROBIC catabolism of fatty acids, amino acids, and carbohydrates  *Endless metabolic connections o Generates high energy intermediates (NADH, FADH , GT2) o Amphibolic • *The citric acid cycle in its most simplest form: o *1) Acetyl-CoA (2C) condenses with oxaloacetate (4C) to make citrate (6C) o *2) Two carbons lost as CO 2 o *3) Oxaloacetate is regenerated o ***Net energy production: 3 NADH, 1 FADH (Q2 ), 2 GTP*** • *Then we start talking about the CAC in detail: o 1) Acetyl-CoA + Oxaloacetate  Citrate  Enzyme Required: citrate synthase  *Reaction creates CoASH (coenzyme A with thioester bond) o 2) Citrate  Isocitrate  Enzyme Required: aconitase o 3) Isocitrate  α-Ketoglutarate  Enzyme Required: isocitrate dehydrogenase  This is an oxida
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