CHAPTER 5 (cont’d)
A. Research with pedigrees
a. DeCODE genetics; we have a genetic counselling program here, we can
look at co-segregation of traits such as color-blindness,
b. Which traits co-segregate? Every part of a person’s family got the
haemophilia and the color blind trait; but one kid with color-blindness
didn’t have haemophilia perhaps the haemophilia gene is linked to the
color blind gene;
c. It’s important to study large pedigrees and preferably individuals with
large pedigrees; although they’re linked, they may not be perfectly linked.
d. DECODE genetics recognizes that there is a power in pedigress and you
can look for a trait/ disease you are interested in with no markers and you
can find DNAthat’s associated with that disease; ideally, with mapping
you have two individuals who have the disease/ not the disease… and then
you can compare co-segregation markers between those people and their
various traits involved.
ii. Cracking the code of Life
iii.There are 3 brothers, one is hairy and the other is bald even though
they’re super similar. Some brothers are sick some are healthy, we
see that a lot of genes are cosegregated.
iv. We observe Iceland, it’s the perfect place to look for genes that
cause disease ans and it has a tiny population of people who live
there, mostly original settlers are Vikings.
v. Iceland has a fantastic written history including everyone’s family
tree; it’s all in the database all your ancestors recorded all the way
to the original Vikings.
vi. Established DECODE technologies and used Icelandic family trees
to bring all data available to try and observe disease cause and
prevention, good idea for diagnosis
vii. First looked for the disease causing arthiritis; her knees hurt really
badly when she was 14, by the age of 39, she had enough and went
to a doctor; 11/17 children had arthritis in the family
viii. DECODE agreed to pay the government 1 million dollars for
Icelandic health records; most of Iceland’s doctors were against
DECODE’s plans; there was something fundamentally wrong
about knowing something about a person’s past, present DNA
structure, and they can predict your future. DECODE was unusual
because DECODE said that genetic information is useless without
the proper relationships, so they needed the medical records they
convinced the Icelandic people to provide unrestricted access to
these records; ix. DECODE ended up going broke 2008, DECODE filed for