IMIN200 Lecture Notes - Lecture 2: Apoptosis, Macrophage, Monocyte

• School: University of Alberta
• Department: Immunology and Infection
• Course: IMIN200
• Professor: Kevin Kane

Document Summary

After studying lecture #2, you should be familiar with the following concepts: self versus non-self. During our lifetimes we face countless assaults from any number of microbial, viral, parasitic and fungal invaders. Thus, an effective immune system requires a detection system that can reliably discriminate between pathogenic. Non-self cells without inducing immune responses against healthy self cells. As we will see, there are two very distinct forms of this immune surveillance system: innate immunity. The innate immune response is the first line of defense against invading microbes and is the sole recognizable immune system in the overwhelming majority of multicellular organisms. The entire repertoire of the innate immune system is encoded within the germline and innate immune responses do not change upon repeat exposure to an infectious or toxic agent. In innate immunity, microbial detection proceeds through the recognition of generic microbial molecules (pathogen associated. Molecular patterns (pamps)) by host pattern recognition receptors (prr): inflammation.