IMIN200 Lecture Notes - Lecture 9: Foxp3, Nod2, Inflammatory Bowel Disease

• School: University of Alberta
• Department: Immunology and Infection
• Course: IMIN200
• Professor: James Stafford

Document Summary

Pathogens that enters inside through the malt or through the gut stopped by them: m cells take up antigen by endocytosis and phagocytosis(cid:224) antigen is transported across the m cells in vesicles and released at the basal surface(cid:224) antigen is bound by dendritic cells, which activate t cells(cid:224) endocytosed bacteria are recognized by tlrs in intracellular vesicles (cid:224) they are also bacteria or their products directly entering the cytosol are recognized by nod1 and. These in turn activate neutrophils, macrophages and dendritic cells: they are basically stuff on the epithelial surface of the galt or malt. Failure leads to inflammatory bowel disease (loss of microbiota)/disease/etc: proteins delivered to the gut create body wide (systemic) tolerance. On the other hand, a control that was just injected produced a huge response: regulatory t cells (treg) made in the gut act in the rest of the periphery.