MMI445 Lecture 9: Lecture 9
4 Mar 2016
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Document Summary
Superficial and systemic mycoses (no relation between superficial and systemic mycoses) Subcutaneous: deep, ulcerated skin lesions, rarely invade deeper tissues. Example case: *erythematous lesions: red lesions, coalesced: joined to make one big lesion. Lesions with raised nodules in centre + peripheral scalin- pet dog- no systemic symptoms, bald. Dermatophyte mould (filamentous fungus), superficial and cutaneous infections, invade keratinized tissue. Tinea (latin-worm, but mould*)- classification based on anatomic infection site, refers to serpentine or annular lesions- ringworm (no association with real worms). Tinea classification: tinea capitis head, tinea corporis trunk, tinea cruris groin, tinea pedis feet, tinea unguium nails. N. b- this is not a genus/species id system. Epidemiology and transmission: ww distribution: some species are restricted to temperate climates, others to tropical. Source of human infection: human- anthropophilic, animal zoophilic, soil geophilic. Pathogenesis: entry via skin breaks or maceration (toes, groin), fungal cells bind keratinocytes. Restricted to body surface- can"t grow @ 37c. Moist environment is favorable- slow growth, chronic infection.
