MICRB316 Lecture Notes - Lecture 10: Hpk, Intracellular Parasite, Pseudomonas Aeruginosa
8 Mar 2014
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Document Summary
There is a wide array of different biological processes controlled by 2 c systems. The number of 2c systems in each bacterial species is highly variable. : 0 (intracellular pathogen) bacillus subtilus: 34 sets. Haemophilus influenzae : 5 hpk; 4 rr synechocystis : 38 sets: coli : 28 sets. But proteins with limited homology have been identified in. Thus, the phosphotransfer rxns catalyzed by hpk & rrs represent an ancient evolutionary signaling mechanism. Archaeal and eukaryotic 2cs have evolved through separate horizontal transfers of bacterial genes. 44 rrs: 24 = ompr- like; 12 = fixj-like; 8. 4 = cheb-like (output domain = esterase activ) 11 = new rrs with conserved receiver domains, but output domains unrelated to known rr"s / each other. 63 hpks: 42/63 are classical it > rr. 5 = chea-like (transmitter domain near n-term), hpt-like. 5 = unorthodox: gene fusion with histidine-containing phosphotransfer module (hpt): itrhpt > rr.
