MMI133 Lecture Notes - Lecture 8: Beta-Lactam, Antimicrobial Resistance, Methicillin

• School: University of Alberta
• Department: Medical Microbiology and Immunology
• Course: MMI133
• Professor: Judy Gnarpe

Document Summary

Note: (take home assignment) question 12: 13 marks; leave one blank. List some probs with chemotherapy for bacteria, viruses, fungi and parasites. Define spectrum of activity, broad-spectrum drugs, mic, sir, drug of choice, bactericidal and bacteriostatic. List 5 modes of activity of antimicrobials and learn the exps given. Explain why monitoring the lvl of some antimicrobial drugs in a pts serum = necessary. List the common superbugs, and id the reason they are classed as superbugs. Some immunoactive substances ie interferon (attempt to mod/amplify response of immune) Overwhelming infection with clostridium perfringens gas gangrene. No antibiotic will be effective if used too late in the infection. Too much tissue damage: rely on blood supply to carry antibiotics around. Formation of walled-off a(cid:271)s(cid:272)esses that (cid:272)a(cid:374)"t (cid:271)e pe(cid:374)etrated (cid:271)y a(cid:374)ti(cid:271)ioti(cid:272)s. Poor absorption of drug: poor absorption in stomach. Damaged the host as much or more than pathogen. 1st synthetic antimicrobial substance to act selectively on bacteria.