MMI133 Lecture Notes - Lecture 1: Bovine Spongiform Encephalopathy, Polio Vaccine, Virus Classification

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Spontaneous Generation - the thought that living things could appear from non living things
Germ Theory of Disease - that microorganisms that spoil milk and broth could also affect living things,
creating disease
Semmelweis - determined that medical employees were spreading germs through their facility, reason
why one in a health care setting must wash their hands now
Pasteur - disproved spontaneous generation experimented with the growth and reduction of
microorganisms
Koch - continued Pasteur’s work by finding the causes of certain diseases (created Koch’s postulates to
confirm is the cause of the disease was a microorganism)
Salk - developed the polio vaccine
A. Size of Microorganisms
Large - worms, parasites, mammals
Medium - microbes (bacteria, algae)
Small - viruses, prions (smaller than viruses, infectious protein molecules that have been misfolded and
does not function properly, e.g. Mad Cow Disease)
Extra Facts
Over 100 trillion bacteria
in the human body, we provide shelter and nutrients such as glycans in milk
(broken down by bacteria), protection against other bacteria, and vitamin K and B12.
Bacterial Flora
can be imbalanced due to antibiotic treatment, virulence factors (molecules from
substances that cause immune invasion)
B. Naming of Bacteria
Organisms Commonly named due to ribosomal sequence.
Family -> Genus -> Species (and rarely subspecies)
E.g. Salmonella typhi
or S. typhi (words are written in italics, with genus capitalized and species
lowercase).
Sp. just indicates the general species group
C. Naming of Viruses
a. Type of nucleic acid
b. Strategy of replication
c. Morphology
Same viral species have same genetic information and niche.
Baltimore and ICTV system are coexisting for naming system.
E.g. Herpes simplex virus 1
Mycology - study of fungi and yeast
Prokaryote (Bacteria)
Small unicellular organisms with no nuclear membrane or membrane bound organelles
Divide by fission
DNA is not enclosed or associated with histones
Start with amino acid/protein formylmethionine
Generally smaller than eukaryotes
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Document Summary

Spontaneous generation - the thought that living things could appear from non living things. Germ theory of disease - that microorganisms that spoil milk and broth could also affect living things, creating disease. Semmelweis - determined that medical employees were spreading germs through their facility, reason why one in a health care setting must wash their hands now. Pasteur - disproved spontaneous generation experimented with the growth and reduction of microorganisms. Koch - continued pasteur"s work by finding the causes of certain diseases (created koch"s postulates to confirm is the cause of the disease was a microorganism) Salk - developed the polio vaccine: size of microorganisms in the human body, we provide shelter and nutrients such as glycans in milk can be imbalanced due to antibiotic treatment, virulence factors (molecules from. Small - viruses, prions (smaller than viruses, infectious protein molecules that have been misfolded and does not function properly, e. g. mad cow disease)

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