MMI133 Lecture Notes - Lecture 28: Lymphogranuloma Venereum, Non-Gonococcal Urethritis, Pelvic Inflammatory Disease
16 Jul 2018
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Document Summary
Disease of the reproductive tract contribute to sti"s. Pid = pelvic inflammatory disease (usually chlamydia or gonorrhea) Cervicitis (inflammation of the cervix), vaginitis, urethritis. May persist and symptoms may recur (very contagious) Lack of immunity: agents are poorly antigenic or have immune evasion capability. Fastidious - adapted to be spread from mucous membrane to mucous membrane (sensitive to dry conditions) Extensive infection - cervix, uterus, fallopian tubes, ovaries. Can spread to peritoneal cavity and cause hepatitis. Over 50% of women with pid are asymptomatic but can have sequelae (complications. Symptoms: lower abdominal pain radiating to back, discharge from vagina. Chlamydia trachomatis is the most common followed by neisseria gonorrhoe ae following) Most common bacterial std : >500 000/year in the usa. Gram - type (lps in cell wall) but cannot use gram stain (infectious particles too small) Unique developmental cycle, with infectious form (eb - elementary bodies) and a metabolically active form (rb - reticulate bodies)
