MMI133 Lecture Notes - Lecture 10: Mast Cell, Leukotriene, Prostaglandin
20 Oct 2015
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Document Summary
Serotonin (comes from platelets in people) - causes vessels to dilate. Leukotrienes - ashma, with prostaglandins (arachidonic acid metabolites) Prostaglandins - most potent (acted on by anti-in ammatory) Clotting cascade, coagulation : domino effect of enzymes being activated. Complement family : about 20 proteins that orchestrates the in ammatory response. Plasma proteins: classical pathway : antibody binds to a virus infected cell, alternative pathway : set of by many different things, can be bacteria products around. Chemotaxis (attracts leukocytes) - make neutrophils move along the chemical gradient. Opsonization (enhances phagocytosis) - protein binds to whatever activated the complement -make it easier for wbc to eat. Neutrophils - key cell type of the acute in ammatory response. Patrol the circulation and look for sites of injury, where the complement system is activated. Margination : move out of the blood stream, waiting for something to activate them. Adhesion : sticks to the lining of blood vessels, and sneak through the wall.
