MMI445 Lecture Notes - Lecture 20: Cysticercosis, Triatominae, Chancre
22 Mar 2016
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Eggs-> miracidia snail 3 generations of maturation released as cercaria infect host by penetrating skin in host: schistosomule, migrates to liver organs of choice. Haematobium: hematuria, microscopic- with dipstick, diagnostic imaging, eggs or adult in urine(only haematobium)/tissue biopsy, Pcr(in research), detection of schistosomal antigen (indicate that you were exposed, not that you were infected) Schistosoma mansoni, japonicum, mekongi: eggs in stool/tissue, fresh examination of rectal biopsy (not histology) put stool between two slides and look for the organisms, diagnostic imaging, pcr, detection of antigen (indicates exposure, not active infection) Once immune system recognize it: eosinophils and lymphocytes (th2: Attaches antibodies in reverse by fc receptor, skin (tegument) is constantly replaced, incorporate host antigens on its own cell surface (abo/rh antigens, ldl, hla) Treatment: praziquantel, artemisinin- for larvae, impared th response will cause susceptibility of infection (hiv) Control: education, clean water, eradication, vaccine (organism is very complex though). Clinical manifestations: chancre, systemic hemolymphatic disease- winterbottom"s sign.
