NURS 116 Lecture Notes - Lecture 13: Allergic Rhinitis, Nasal Administration, Methylprednisolone
14 Feb 2019
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Document Summary
Pd well absorbed, 60-90% bioavailability wide volume of distribution and is lipophilic sulfation and glucuronidation excreted by the kidney, half life of 1-6 hours short acting: hydrocortisone, cortisone, prednisone, prednisolone, methylprednisolone long acting: dexamethasone. Acetaminophen/tylenol - treat pain and systemic heat (fever) paracetamol: european name. Mechanism: weak inhibitors in peripheral tissue, which account for the antiinflammatory effect. Release of tissue thromboplastin to facilitate hemostasis (clotting), promoting fibroblast activity. Healing processes might be interrupted by re-injury or renewed inflammation. May be subclinical, with elevated c-reactive protein (crp) or erythrocyte sedimentation rate. Blood tests used to identify serious infection in acutely ill children, also assessing for cv risks (esr) in metabolic disorders and type ii diabetes. Low grade chronic inflammation - associated with systemic manifestations including body aches, pains, frequent infections, diarrhea, dry eyes, shortness of breath and unipolar depression. Localized symptoms - depend on the degree of injury and the resistance of host to injury.
