NURS215 Lecture Notes - Lecture 8: Muscarinic Acetylcholine Receptor, Sympathetic Nervous System, Nicotinic Acetylcholine Receptor

• School: University of Alberta
• Department: Nursing
• Course: NURS215
• Professor: Helena Schaefer

Document Summary

Neurology pharmacotherapeutics part i: olson: chpts 2 & 3, adams: chpts 12-21, 24, neuro=nervous system, peripheral ns, autonomic: sympathetic & parasympathetic. Outside of voluntary control: vascular & smooth muscle, cardiac, metabolism, exocrine & endocrine control, nervous system synapses, somatic. Neuromuscular synapses: neurons: pre & post ganglionic, neurotransmitter (nt) summary, ach: peripheral & central nt. Preganglionic synapse in pns & sns (nicotinic) Somatic ns= binds to muscle receptors (nicotinic: => ca influx & contraction. Cns neurotransmitter (muscarinic: norepi: peripheral & central nt. Ca, na influx & k efflux in nervous system activity: y(cid:374)apti(cid:272) (cid:272)left , neurotransmitters bind to specific receptors. Degraded by enzymes: comt, mao, cholinesterase. Agonists: sns: (cid:858)cate(cid:272)hola(cid:373)i(cid:374)es(cid:859, aka adrenergics, aka sympathomimetics, end result =stimulate the sns, pns: (cid:858)choli(cid:374)o(cid:373)i(cid:373)eti(cid:272)s(cid:859, aka muscarinics, end result = stimulate the pns (cid:858)(cid:272)ate(cid:272)hola(cid:373)i(cid:374)es(cid:859, stimulate sympathetic nervous system. Especially if it is non-selective: depends on receptor specificity, cholinomimetics (stimulate pns, stimulate acetylcholine. Pilocarpine (decrease intraocular pressure: clinical use: glaucoma tx, ide effe(cid:272)ts: (cid:858)(cid:272)holi(cid:374)ergi(cid:272)(cid:859) effe(cid:272)ts.