NURS391 Lecture Notes - Lecture 1: Diuresis, Diabetes Mellitus Type 1, Postprandial

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Insulin is secreted by beta cells, which are one of the cells in islets of langerhans located in pancreas. Insulin is an anabolic, or storage, hormone helps move glucose from blood into muscle, liver, fat cells. Funcions are: o o o o o o. Simulates storage of glucose in liver and muscle (in the form of glycogen) Signals the liver to stop the release of glucose. Enhances storage of dietary fat in adipose issue. Accelerates transport of amino acids (derived from dietary protein) into cells. Characterized by destrucion of pancreaic beta cells = decreased insulin producion: glucose derived from food cannot be stored in liver but instead remains in bloodstream and contributes to o o postprandial (ater meals) hyperglycemia. If concentraion of glucose in blood exceeds renal threshold for glucose (usually 9. 9-11. 1), kidneys may not reabsorb all of iltered glucose = glucose in urine = accompanied by excessive loss of luids and electrolytes = osmoic diuresis.

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