PEDS101 Lecture Notes - Lecture 9: Sliding Filament Theory, Pearson Education, Autonomic Nervous System
Muscles
Chapter 12a
Copyright © 2009 Pearson Education, Inc.
© 2013 Pearson Education, Inc.
Overview
•Part 1 Overview
•Muscle types and functions
•Part 2. Muscle structure
•Ultrastructure
•
The
sarcomere
Copyright © 2009 Pearson Education, Inc.
•
The
sarcomere
•Contractile proteins
•Part 3. Excitation-contraction coupling
•Molecular basis of contraction
•Sliding filament theory
•Role of calcium and ATP
Nucleus
Muscle fiber
(cell)
Striations
Skeletal muscle fibers are large,
multinucleate cells that appear
striped or striated under the
microscope.
Part 1. Overview- three types of muscle
Nucleus
Muscle fiber
Intercalated
Cardiac muscle fibers are also
striated but they are smaller,
branched, and uninucleate. Cells
are joined in series by junctions
called intercalated disks.
•attached to and moves bones
•regulated by somatic n.s.
nervous system
•
pumps blood
Copyright © 2009 Pearson Education, Inc.
Intercalated
disk
Striations
Nucleus
Muscle fiber
Smooth muscle fibers are small
and lack striations.
•
pumps blood
•regulated by autonomic
nervous system and chemical
signals (e.g. hormones)
•surrounds organs/vessels
•regulated by autonomic
nervous system and chemical
signals (e.g. hormones)
Document Summary
Skeletal muscle fibers are large, multinucleate cells that appear striped or striated under the microscope: attached to and moves bones, regulated by somatic n. s. nervous system. Cardiac muscle fibers are also striated but they are smaller, branched, and uninucleate. Cells are joined in series by junctions called intercalated disks: pumps blood, pumps blood, regulated by autonomic nervous system and chemical signals (e. g. hormones) Smooth muscle fibers are small and lack striations: surrounds organs/vessels, regulated by autonomic nervous system and chemical signals (e. g. hormones) For smooth and cardiac muscle, there is antagonistic control. A group of muscle fibres bundled together in connective tissue is a muscle fascicle. Sarcolemma- muscle fibre membrane, carries action potential along muscle fibre. Thick and thin filaments contract and slide together and is what allows for contacting of each myofibril. A single muscle cell is a multinucleated muscle fibre that contains many myofibrils (b) T-tubules- carry action potentials deep into muscle fibre.