PEDS200 Lecture : Hormones-1
Document Summary
Release depends on type (positive or negative) and magnitude (amount of releasing factor) Stimulation by: neural response, other hormones, humoral (compounds in blood) Reduction/removal: decrease neural activity/humoral stimuli (negative feedback, metabolized in liver/kidney, excreted in urine/bile. 1. metabolic hormones: gh-anterior pituitary: incr. mobilization of fatty acids, decr. glycogen use, thyroxine-thyroid: incr. Rmr: cortisol: incr. gluconeogenesis, epinephrine: incr. glycogen breakdown, incr. Hr and contractility: insulin-pancreas: incr. glucose and amino acid uptake, incr. synthesis of fat, glucagon-pancreas: incr. glucose release from liver, incr. breakdown of fats. Growth hormone: incr. cell growth & protein synthesis. Cortisol and to a lesser extent glucagon: incr. protein & incr. production of glucose breakdown. Induce secretory activity: exercise incr. thyrotropin releasing factor produced by hypothalamus, acts on ant. pituitary to produce thyrotropin which stimulates secretion of thyroxin from thyroid. incr. metabolic rate, hr. Alter particular enzyme activity: exercise can incr. epinephrine & initiate second messenger system, incr. breakdown of muscle glycogen.