PHYSL402 Lecture Notes - Lecture 9: Ghrelin, Autocrine Signalling, Main Source
13 Oct 2016
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Zinc = controversial (inhibit glucagon vs. no effects of beta cell secretion effects on. Islet amyloid polypeptide + its role in pathogenesis in diabetes. (other hormones are transiently expressed during development eg. gastrin, ghrelin) Paracrine substances are also released from islet cells eg. gaba, zn2+ glucagon) Increase in blood glucose amylin secretion (do not want glucose to go too high slowing entry of glucose into intestine) accelerated gastric emptying) Cause of beta cell death? b/c do see beta cell loss in diabetes. With high demand of insulin, get increased amylin secretion (shear [ ] may in fact be. Formed b/c of its aa structure (image): folds in beta pleated sheets b/c of gail. Some of the potential effects of amylin aggregates and folding up and joining together. Physical barrier created by aggregates can be a problem (greater diffuse and increase nutrient transport distance) Another interesting fact: can into membrane of beta cell (cid:894)(cid:862)(cid:271)ad(cid:863) para(cid:272)ri(cid:374)e fu(cid:374)(cid:272)tio(cid:374)
