PMCOL305 Lecture Notes - Lecture 15: Partial Agonist, Stim, Organic Chemistry
27 Oct 2016
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To learn the medical consequences of cannabis use. Understand the constituents of spice and why they are dangerous. To learn why vaporizers may be a less dangerous way of using cannabis. To investigate the pathways (use many pathways) linked to increased food intake. Examine the consequences of cannabis use on driving. Tolerance and withdrawal (is there such thing as withdrawal; can you become addicted?) With chronic thc exposure, cb1 rs are internalized (removed from the neuronal membrane) Become tolerant to thc as well as own endocannabinoids. Hot flashes, sweating, runny nose, loose stools, irritability, anxiety, insomnia. Usually not severe b/c of long half-life of drug and metabolites results in very gradual decrease; may have body stores that leach out (not much evidence for dependence) Some sources claim marijuana smoke has 50-70 % more carcinogenic material than cig smoke. Other sources say basically similar levels in both.
