PSYCO275 Lecture Notes - Lecture 5: Chemical Synapse, Neurotransmitter Receptor, Membrane Potential

• School: University of Alberta
• Department: Psychology
• Course: PSYCO275
• Professor: Clayton Dickson

Document Summary

Directional; must be pre-synaptic (storage and release) to post-synaptic (receptors) Potential causes a graded change in post-synaptic potential. Gap junction: fused presynaptic and postsynaptic membrane that allows an action potential to pass. Nt travels across synapse and then binds postsynaptic receptor. Postsynaptic channels change state and changes postsynaptic membrane potential. Nt vesicles fuse with membrane and release contents into synaptic cleft. Temporal summation: rapid succession sum to produce larger epsp or ipsp from same input. Spatial summation: different input locations occurring at the same time. If nt is in the cleft, it is active ; activity must somehow be terminated. When the neuron is active, chemical must be released and produce a response. Same response must be obtained when the chemical is experimentally placed on the target. Ap will be the same across the same type of neuron. Ach, amines (da, ne, ep, 5-ht), amino acids (glu, gaba, gly) Synthesized through translation of mrna from instructions in neuron"s dna.