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Chapter 9.docx

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NURS 201
Marywyatt Sindlinger

Chapter 9  Coronary artery disease (CAD) is a type of blood vessel disorder included in the general category of atherosclerosis.  Atherosclerosis is characterized by a focal deposit of cholesterol and lipids within the intimal wall of the artery. Inflammation and endothelial injury play a central role in the development of atherosclerosis.  CAD is a progressive disease that develops in stages and when it becomes symptomatic, the disease process is usually well advanced.  Normally some arterial anastomoses or connections, termed collateral circulation, exist within the coronary circulation. The growth and extent of collateral circulation are attributed to two factors: (1) the inherited predisposition to develop new blood vessels (angiogenesis), and (2) the presence of chronic ischemia.  Many risk factors have been associated with CAD. o Nonmodifiable risk factors are age, gender, ethnicity, family history, and genetic inheritance. o Modifiable risk factors include elevated serum lipids, hypertension, tobacco use, physical inactivity, obesity, diabetes, metabolic syndrome, psychologic states, and homocysteine level.  Elevated serum lipid levels are one of the four most firmly established risk factors for CAD.  Lipids combine with proteins to form lipoproteins and are vehicles for fat mobilization and transport. The different types of lipoproteins are classified as high-density lipoproteins (HDLs), low-density lipoproteins (LDLs), and very-low-density lipoproteins (VLDLs).  HDLs carry lipids away from arteries and to the liver for metabolism. High serum HDL levels are desirable.  HDL levels are increased by physical activity, moderate alcohol consumption, and estrogen administration.  Elevated LDL levels correlate most closely with an increased incidence of atherosclerosis and CAD.  Hypertension, defined as a BP greater than or equal to 140/90 mm Hg, is a major risk factor in CAD.  Tobacco use is also a major risk factor in CAD. The risk of developing CAD is two to six times higher in those who smoke tobacco than in those who do not.  Obesity is defined as a body mass index (BMI) of less than 30 kg/m . The increased risk for CAD is proportional to the degree of obesity. o Diabetes, metabolic syndrome, and certain behavioral states (i.e., stress) have also been found to be contributing risk factors for CAD. CORONARY ARTERY DISEASE  Prevention and early treatment of CAD must involve a multifactorial approach and needs to be ongoing throughout the lifespan  A complete lipid profile is recommended every 5 years beginning at age 20. Persons with a serum cholesterol level greater than 200 mg/dl are at high risk for CAD.  Management of high-risk persons starts with controlling or changing the additive effects of modifiable risk factors. o A regular physical activity program should be implemented. o Therapeutic lifestyle changes to reduce the risk of CAD include lowering LDL cholesterol by adopting a diet that limits saturated fats and cholesterol and emphasizes complex carbohydrates (e.g., whole grains, fruit, vegetables). o Low-dose aspirin is recommended for people at risk for CAD. Aspirin therapy is not recommended for women with low risk for CAD before age 65. Common side effects of aspirin therapy include GI upset and bleeding. For people who are aspirin intolerant, clopidogrel (Plavix) can be considered.  If levels remain elevated despite modifiable changes, drug therapy is considered. o Statin drugs work by inhibiting the synthesis of cholesterol in the liver. Liver enzymes must be regularly monitored. o Niacin, a water-soluble B vitamin, is highly effective in lowering LDL and triglyceride levels by interfering with their synthesis. Niacin also increases HDL levels better than many other lipid-lowering drugs. o Fibric acid derivatives work by accelerating the elimination of VLDLs and increasing the production of apoproteins A-I and A-II. o Bile-acid sequestrants increase conversion of cholesterol to bile acids and decrease hepatic cholesterol content. The primary effect is a decrease in total cholesterol and LDLs. o Certain drugs selectively inhibit the absorption of dietary and biliary cholesterol across the intestinal wall.  The incidence of cardiac disease is greatly increased in the elderly and is the leading cause of death in older persons. Strategies to reduce CAD risk are effective in this age group but are often underprescribed.  Aggressive treatment of hypertension and hyperlipidemia will stabilize plaques in the coronary arteries of older adults, and cessation of tobacco use helps decrease the risk for CAD at any age. CHRONIC STABLE ANGINA  Chronic stable angina refers to chest pain that occurs intermittently over a long period with the same pattern o
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