ANSC 3080 Lecture Notes - Lecture 20: Gonadal Ridge, Development Of The Gonads, Reproductive System
29 Oct 2018
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Document Summary
Formation of primordial germ cells (p. g. cs)- become germ cells. Colonize the genital ridge to form indifferent gonads. Differentiation of cortex into ovary or medulla into testis- testis organization through transient expression of genes (testes differentiation factor-tdf) from the sry (sex-determining region y) **key event**activation of a gene from the sex-determining region y: multiply, migrate and multiply again, home at gonadal ridge. Eventually in males, the wolffian duct remains and in females, the mullerian duct remains. If you have a y chromosome, expression in tdf (acts locally, gene encoded in the sry) Mesonephric mesenchyme connective tissue (tunica albuginae), blood vessels, leydig cells (produce testosterone) Testosterone stimulates the development of the mesonephric duct. Second generation of cord epithelium form primordial follicle. Mesonephric tubules regress to form a rudimentary rete. Pgc will invade and migrate toward the periphery (cortex) Surrounded by layers of cells that will organize the pgcs in primordial follicles.
