NUTR 3210 Lecture Notes - Lecture 9: Lingual Lipase, Bile Acid, Phospholipase A2
7 Feb 2017
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Process: desaturation (double bond added to position 6, elongation (2 hydrogens added at the carboxyl end, desaturation (double bond added at position 5) Metabolites typically make from 20c fa (aa and epa) Produced by most cells in the body. (cid:858)hor(cid:373)o(cid:374)e-like(cid:863), lo(cid:272)al fu(cid:374)(cid:272)tio(cid:374: role in inflammation, platelet aggregation, blood pressure, etc. Implications for disease prostaglandins (pgd2) thromboxanes (txa2) leukotrienes (lte4) Pla2 clips off fatty acid for eicosanoid production (corticosteroids uninflammatory inhibitors inhibit pla2 to reduce inflammation: lipoxygenase (lox) The linear pathway: cycloxygenase (cox) (aspirin and ibuprofen inhibit cox enzymes to reduce inflammation) When you start taking omega-3 fatty acid supplements, and this creates more precursors for eicosanoid production for anti-inflammatory benefits. Ester bonds are what join the fatty acids to the glycerol back bone. Important in several key pathways: lipogenesis (production of new fat; stored in triglycerides, lipolysis (access of energy in fat; breaking down of triglycerides) Structure: monoacylglycerol (mg, mag, diacylglycerol (dg, dag, triacylglycerol/triglyceride (tg, tag)
