NUTR 3210 Lecture Notes - Lecture 14: High-Protein Diet, Cori Cycle, Citric Acid Cycle
7 Mar 2017
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Must maintain: blood glucose between 60-100mg/dl (< 60mg/dl you develop, a coma and death) insulin helps regulate this, blood ph near neutrality (related to nh3 handling) Blood glucose is: always required by rbc as energy substrate (no mitochondria, required by central nervous system (although gradual adaptation to ketones possible, maintain an active kreb"s cycle. Metabolic state and predominant source of blood glucose: fed dietary cho (if high carbs), dietary protein (if high protein diet, post-absorptive (2 hour period after meal) glycogen from liver (direct) and muscle (indirect) Insulin does a lot in the fed state: glucagon is present in the post-absorptive state, glucagon promotes gluconeogenesis, catecholamine"s promote fat breakdown in adipose tissue (want glycolysis) Fed state 90% urea, 10% nh4: 0-2 hours period after eating, high blood glucose and glucogenic aa, glucose uptake and glycogen formation promoted first in liver, then in muscle, aa catabolized by liver (first-pass metabolism)
