NUTR 3210 Lecture Notes - Lecture 8: Branched-Chain Amino Acid, Myocyte, Urea Cycle
27 Jul 2016
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Document Summary
Carbon skeleton metabolism metabolization of energy from amino acid carbon skeletons. Goals of metabolic integration: the goal of metabolism is to maintain certain physiological parameters within their normal" homeostatic range, including, blood glucose: must be maintained between 4-6 mmol/l. Glucose is essential fuel for the brain and is also required by red blood cells. It maintains the tca cycle in cells during fatty acids as fuel: blood ph: must be maintained near neutrality 7. 1-7. 4. There are many short term buffers, but long term control is exerted by route of nitrogen excretion. Metabolism in different tissues: liver: glucose uptake in the liver is not regulated by insulin. The liver is the primary site of gluconeogenesis: it is a major site for fat metabolism, including lipolysis and lipogenesis, and lipoprotein assembly and degradation, only tissue that produces ketone bodies. Fatty acids (mainly from adipose tissue) are the predominant source of energy for slow twitch muscle: fast-twitch: used for short duration, quick contraction.
