NUTR 3210 Lecture 13: NUTR3210 - LEct 13

• School: University of Guelph
• Department: Nutrition
• Course: NUTR 3210
• Professor: David Mutch

Document Summary

Marasmus & kwashiorkor: we"(cid:448)e treated these t(cid:449)o (cid:272)o(cid:374)ditio(cid:374)s as disti(cid:374)(cid:272)t, (cid:271)ut the reality is that (cid:271)oth typi(cid:272)ally (cid:272)o- exist along a spectrum, acute problem: dietary challenge sets in and there is no change, then mortality occurs in. 1-2 months: chronic problem: dietary challenge comes and goes, so people typically survive but are quite ill for several months or years at a time, both lead to immune dysfunction. Reactions of protein catabolism: constant turnover between protein synthesis and breakdown, during protein breakdown, the body is very efficient at aa reutilization (~80% aa reused, the remaining degraded) This allows hco# to be used to neutralize the weak acidotic state. Important aa in nitrogen metabolism: glutamate (also an excellent acceptor of nh3, source of free nh3, end product of transamination reactions, alpha-ketoacid is alpha-ketoglutarate, aspartate, carries nitrogen in the urea cycle, alpha-ketoacid is oxaloacetate, alanine. Inter-organ nitrogen carrier (goes to the liver: alpha-ketoacid is pyruvate, glutamine.