NUTR 3210 Lecture 9: Unit 9

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The ligand then moves into the nucleus, which is the binding location for type ii shr, in contrast to type i which binds in the cytosol. When the ligand binds, it forms a ligand/receptor complex: the ligand/receptor complex is active as a transcription factor, and binds to the promoter region of a gene. This binding usually increases the transcription of mrna, but binding can also inhibit transcription: after mrna is transcribed, it moves out of the nucleus to the rougher er, where the nucleotide sequence is translated into protein structure. Post-translational modi cations may be required for full activity of the protein. Steroid and non steroid ligands the nomenclature steroid hormone receptor is a bit misleading, since most of the ligands that bind to these receptors are not steroid hormones steroid hormones are derived from cholesterol. People in many countries, even in geographically de cient area, are exposed to adequate iodide because of forti cation of salt.

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