NUTR 4090 Lecture Notes - Lecture 10: High-Throughput Screening, Reactive Oxygen Species, Nutraceutical
17 Apr 2018
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Document Summary
Frequent and high consumption of alcohol can lead to cancer. Approved risk reduction claim: a healthy diet rich in veggies and fruit may reduce risk of some types of cancer. A health claim for dietary fibres & cancer is not approved in canada. There are certain chemicals that can cause dna damage. If dna damage can pass on to future cells, it can cause tumour. If ros is stopped, we can prevent damage. Inflammation promotes cancer because there are high amounts of ros. Antioxidants may be able to block initiation events and reduce promotion, which reduces ros. Inflammation at basic function is a healing process (good inflammation) Reducing low-grade chronic inflammation (bad inflammation) will have beneficial effect. Ros is critical to cell signaling, basal levels of ros is normal, ros is not bad but the problem is when you have imbalance of sources. We have endogenous antioxidant systems that ensure ros levels stay within limit.
