BGEN 3020 Lecture Notes - Superoxide, Unpaired Electron, Glutathione

• School: University of Manitoba
• Department: Biochem. and Medical Genetics
• Course: BGEN 3020
• Professor: Jason Leboe- Mcgowan

Document Summary

In the scenario with a bee sting: you will see redness (tubor). The king of vasodilators is histamine and it vasodilates the arterioles. Therefore, histamine is responsible for the redness of acute inflammation (ie bee sting), and is working on arterioles. Now if we felt the area, it will be warm (calor = heat), this is due to vasodilating the arterioles, which is caused by histamine. For example in endotoxic and septic shock, the skin is warm b/c you are vasodilated. Tumor is a raised structure caused by histamine. The venules are very thin; they basically have an endothelial cell with a basement membrane, all you have to is drill a hole through the bm and you are out. Therefore, increased vessel permeability occurs at the venule level, not the arterial level. Histamine contracts the endothelial cells, and leaves the bm bare, leading to increased vessel permeability, producing an exudate, and swelling of tissue, hence tumor of acute inflammation.