BGEN 3020 Lecture Notes - Lymphangiosarcoma, Scrotum, Bee Sting

• School: University of Manitoba
• Department: Biochem. and Medical Genetics
• Course: BGEN 3020
• Professor: Jason Leboe- Mcgowan

Document Summary

Edema excess fluid in the interstitial space, which is extracellular fluid (ecf); this is outside the vessel. Types of edema: non-pitting edema increased vessel permeability with pus in the interstial space (pus=exudates). Lymphatic fluid is another type of non-pitting edema. Blockage of lymphatics leads to lymphatic fluid in the interstial space. Exudates and lymphatic fluid does not pit: pitting edema transudate with right heart failure, swelling of the lower extremities, fluid in the interstial space. Transudate does pit: so there are three things that cause edema: exudates, lymphedema, and transudate, and transudates are the only one that has pitting edema. 80% of our oncotic pressure is related to the serum albumin levels. Anytime there is hypoalbuminemia then we will have a leaking of a transudate (protein of less than 3 g/dl) leaking into interstial space via capillaries and venules (pitting edema): normally, hydrostatic pressure is trying to push fluid out. Therefore, in a normal person, oncotic pressure is winning.